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Formulation is 1% (v/v) solution of ethanol/solutol/water (10/40/50%)
The effective concentration-50% (EC50) of GS 441524 is calculated to be 0
3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4
CAS Number: 244240-24-2
E 2012 - CAS# 870843-42-8 Size:Solid 2 mg Formulation is 1% (v/v) solutionE2012 is a secretase modulator (GSM). E2012 inhibits 3 hydroxysterol 24 reductase (DHCR24) at the final step in the cholesterol biosynthesis. E2012 induces cataract in the rat by inhibiting DHCR24 at the final step of cholesterol synthesis with associated elevation in desmosterol within the lens, preceded by desmosterol changes that would serve as a predictive safety biomarker for lenticular opacity. Product information CAS Number: 870843 42 8
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